Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.

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Detalles Bibliográficos
Autores principales: Mohammed D. Aljohani, Sonia El Mouridi, Monika Priyadarshini, Amhed M. Vargas-Velazquez, Christian Frøkjær-Jensen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a8c5b4807bab427487293c18ed3e5c8d
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Sumario:C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.