Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.

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Autores principales:	Mohammed D. Aljohani, Sonia El Mouridi, Monika Priyadarshini, Amhed M. Vargas-Velazquez, Christian Frøkjær-Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8c5b4807bab427487293c18ed3e5c8d
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spelling	oai:doaj.org-article:a8c5b4807bab427487293c18ed3e5c8d2021-12-02T13:27:23ZEngineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans10.1038/s41467-020-19898-02041-1723https://doaj.org/article/a8c5b4807bab427487293c18ed3e5c8d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19898-0https://doaj.org/toc/2041-1723C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.Mohammed D. AljohaniSonia El MouridiMonika PriyadarshiniAmhed M. Vargas-VelazquezChristian Frøkjær-JensenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohammed D. Aljohani Sonia El Mouridi Monika Priyadarshini Amhed M. Vargas-Velazquez Christian Frøkjær-Jensen Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
description	C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.
format	article
author	Mohammed D. Aljohani Sonia El Mouridi Monika Priyadarshini Amhed M. Vargas-Velazquez Christian Frøkjær-Jensen
author_facet	Mohammed D. Aljohani Sonia El Mouridi Monika Priyadarshini Amhed M. Vargas-Velazquez Christian Frøkjær-Jensen
author_sort	Mohammed D. Aljohani
title	Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
title_short	Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
title_full	Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
title_fullStr	Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
title_full_unstemmed	Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
title_sort	engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in c. elegans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a8c5b4807bab427487293c18ed3e5c8d
work_keys_str_mv	AT mohammeddaljohani engineeringrulesthatminimizegermlinesilencingoftransgenesinsimpleextrachromosomalarraysincelegans AT soniaelmouridi engineeringrulesthatminimizegermlinesilencingoftransgenesinsimpleextrachromosomalarraysincelegans AT monikapriyadarshini engineeringrulesthatminimizegermlinesilencingoftransgenesinsimpleextrachromosomalarraysincelegans AT amhedmvargasvelazquez engineeringrulesthatminimizegermlinesilencingoftransgenesinsimpleextrachromosomalarraysincelegans AT christianfrøkjærjensen engineeringrulesthatminimizegermlinesilencingoftransgenesinsimpleextrachromosomalarraysincelegans
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Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

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