Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans
C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.
Enregistré dans:
Auteurs principaux: | Mohammed D. Aljohani, Sonia El Mouridi, Monika Priyadarshini, Amhed M. Vargas-Velazquez, Christian Frøkjær-Jensen |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/a8c5b4807bab427487293c18ed3e5c8d |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
par: Konstantin Helmsauer, et autres
Publié: (2020) -
Protein-Mediated and RNA-Based Origins of Replication of Extrachromosomal Mycobacterial Prophages
par: Katherine S. Wetzel, et autres
Publié: (2020) -
Contrasting epigenetic control of transgenes and endogenous genes promotes post-transcriptional transgene silencing in Arabidopsis
par: Nicolas Butel, et autres
Publié: (2021) -
Replication independent formation of extrachromosomal circular DNA in mammalian cell-free system.
par: Zoya Cohen, et autres
Publié: (2009) -
The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans
par: Wenjing Qi, et autres
Publié: (2021)