A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease

A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease

Despite the high prevalence of prostate cancer in older men, the predictive value of a polygenic risk score (PRS) remains uncertain in men aged ≥70 years. We used a 6.6 million-variant PRS to predict the risk of incident prostate cancer in a prospective study of 5701 men of European descent aged ≥70...

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Autores principales: Andrew Bakshi, Moeen Riaz, Suzanne G. Orchard, Prudence R. Carr, Amit D. Joshi, Yin Cao, Richard Rebello, Tú Nguyen-Dumont, Melissa C. Southey, Jeremy L. Millar, Lucy Gately, Peter Gibbs, Leslie G. Ford, Howard L. Parnes, Andrew T. Chan, John J. McNeil, Paul Lacaze
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
prostate cancer
polygenic risk score
Gleason grade
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/a8ca762ddd664e1c850cc3d6c9ef4b84
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https://doaj.org/article/a8ca762ddd664e1c850cc3d6c9ef4b84

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