A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease

Despite the high prevalence of prostate cancer in older men, the predictive value of a polygenic risk score (PRS) remains uncertain in men aged ≥70 years. We used a 6.6 million-variant PRS to predict the risk of incident prostate cancer in a prospective study of 5701 men of European descent aged ≥70...

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Bibliographic Details
Main Authors:	Andrew Bakshi, Moeen Riaz, Suzanne G. Orchard, Prudence R. Carr, Amit D. Joshi, Yin Cao, Richard Rebello, Tú Nguyen-Dumont, Melissa C. Southey, Jeremy L. Millar, Lucy Gately, Peter Gibbs, Leslie G. Ford, Howard L. Parnes, Andrew T. Chan, John J. McNeil, Paul Lacaze
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	prostate cancer polygenic risk score Gleason grade Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Online Access:	https://doaj.org/article/a8ca762ddd664e1c850cc3d6c9ef4b84
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A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease

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