Durable targeting of B-lymphocytes in living mice

Abstract Transfer to and enduring expression of genes in B cells has proved a vexing challenge. We report here a novel method for the specific and durable targeting of B lymphocytes in living mice. The method involves generation of lentiviruses pseudotyped with an anti-CD19 antibody. CD19 targeting...

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Autores principales: M. Cascalho, D. Huynh, A. R. Lefferts, L. Stein, T. Lanigan, J. Decker, L. D. Shea, J. L. Platt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a8d8bc5a0ace45508e8d50d4287059cd
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