Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induc...

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Autores principales: Ryan J. Geusz, Allen Wang, Dieter K. Lam, Nicholas K. Vinckier, Konstantinos-Dionysios Alysandratos, David A. Roberts, Jinzhao Wang, Samy Kefalopoulou, Araceli Ramirez, Yunjiang Qiu, Joshua Chiou, Kyle J. Gaulton, Bing Ren, Darrell N. Kotton, Maike Sander
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/a8ff109def3c49e6a1431185b2073726
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https://doaj.org/article/a8ff109def3c49e6a1431185b2073726

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