Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induc...
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Nature Portfolio
2021
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oai:doaj.org-article:a8ff109def3c49e6a1431185b20737262021-11-21T12:36:03ZSequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors10.1038/s41467-021-26950-02041-1723https://doaj.org/article/a8ff109def3c49e6a1431185b20737262021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26950-0https://doaj.org/toc/2041-1723Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induction, whereas the majority do not undergo chromatin priming and engage FOXA upon lineage induction.Ryan J. GeuszAllen WangDieter K. LamNicholas K. VinckierKonstantinos-Dionysios AlysandratosDavid A. RobertsJinzhao WangSamy KefalopoulouAraceli RamirezYunjiang QiuJoshua ChiouKyle J. GaultonBing RenDarrell N. KottonMaike SanderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
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DOAJ |
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| language |
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| topic |
Science Q |
| spellingShingle |
Science Q Ryan J. Geusz Allen Wang Dieter K. Lam Nicholas K. Vinckier Konstantinos-Dionysios Alysandratos David A. Roberts Jinzhao Wang Samy Kefalopoulou Araceli Ramirez Yunjiang Qiu Joshua Chiou Kyle J. Gaulton Bing Ren Darrell N. Kotton Maike Sander Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors |
| description |
Enhancers for endodermal organs are primed at the chromatin level prior to lineage induction by FOXA pioneer transcription factors; how pervasive this is, is not well known. Here the authors show that only a small subset of organ-specific enhancers are bound and primed by FOXA prior to lineage induction, whereas the majority do not undergo chromatin priming and engage FOXA upon lineage induction. |
| format |
article |
| author |
Ryan J. Geusz Allen Wang Dieter K. Lam Nicholas K. Vinckier Konstantinos-Dionysios Alysandratos David A. Roberts Jinzhao Wang Samy Kefalopoulou Araceli Ramirez Yunjiang Qiu Joshua Chiou Kyle J. Gaulton Bing Ren Darrell N. Kotton Maike Sander |
| author_facet |
Ryan J. Geusz Allen Wang Dieter K. Lam Nicholas K. Vinckier Konstantinos-Dionysios Alysandratos David A. Roberts Jinzhao Wang Samy Kefalopoulou Araceli Ramirez Yunjiang Qiu Joshua Chiou Kyle J. Gaulton Bing Ren Darrell N. Kotton Maike Sander |
| author_sort |
Ryan J. Geusz |
| title |
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors |
| title_short |
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors |
| title_full |
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors |
| title_fullStr |
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors |
| title_full_unstemmed |
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors |
| title_sort |
sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by foxa pioneer factors |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a8ff109def3c49e6a1431185b2073726 |
| work_keys_str_mv |
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