Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.

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Autores principales: Elizabeth L. Johnson, Stacey L. Heaver, Jillian L. Waters, Benjamin I. Kim, Alexis Bretin, Andrew L. Goodman, Andrew T. Gewirtz, Tilla S. Worgall, Ruth E. Ley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a946ac4716d946b782e0ae26fb93f95f
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