Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.

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Autores principales:	Elizabeth L. Johnson, Stacey L. Heaver, Jillian L. Waters, Benjamin I. Kim, Alexis Bretin, Andrew L. Goodman, Andrew T. Gewirtz, Tilla S. Worgall, Ruth E. Ley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a946ac4716d946b782e0ae26fb93f95f
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spelling	oai:doaj.org-article:a946ac4716d946b782e0ae26fb93f95f2021-12-02T15:45:24ZSphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels10.1038/s41467-020-16274-w2041-1723https://doaj.org/article/a946ac4716d946b782e0ae26fb93f95f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16274-whttps://doaj.org/toc/2041-1723Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.Elizabeth L. JohnsonStacey L. HeaverJillian L. WatersBenjamin I. KimAlexis BretinAndrew L. GoodmanAndrew T. GewirtzTilla S. WorgallRuth E. LeyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth L. Johnson Stacey L. Heaver Jillian L. Waters Benjamin I. Kim Alexis Bretin Andrew L. Goodman Andrew T. Gewirtz Tilla S. Worgall Ruth E. Ley Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
description	Ceramides are a type of sphingolipid (SL) that have been shown to play a role in several metabolic disorders. Here, the authors investigate the effect of SL-production by gut Bacteroides on host SL homeostasis and show that microbiome-derived SLs enter host circulation and alter ceramide production.
format	article
author	Elizabeth L. Johnson Stacey L. Heaver Jillian L. Waters Benjamin I. Kim Alexis Bretin Andrew L. Goodman Andrew T. Gewirtz Tilla S. Worgall Ruth E. Ley
author_facet	Elizabeth L. Johnson Stacey L. Heaver Jillian L. Waters Benjamin I. Kim Alexis Bretin Andrew L. Goodman Andrew T. Gewirtz Tilla S. Worgall Ruth E. Ley
author_sort	Elizabeth L. Johnson
title	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_short	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_full	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_fullStr	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_full_unstemmed	Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
title_sort	sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a946ac4716d946b782e0ae26fb93f95f
work_keys_str_mv	AT elizabethljohnson sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT staceylheaver sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT jillianlwaters sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT benjaminikim sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT alexisbretin sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT andrewlgoodman sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT andrewtgewirtz sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT tillasworgall sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels AT rutheley sphingolipidsproducedbygutbacteriaenterhostmetabolicpathwaysimpactingceramidelevels
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Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

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