Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

Abstract ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling small changes in cytosolic Ca2+ to trigger large changes in channel activity. With recent landmark determinations of the full structures of RyR1 (skeletal isoform) and RyR2 using cryo-EM, and identifi...

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Autores principales: Chris Lindsay, Mano Sitsapesan, Wei Mun Chan, Elisa Venturi, William Welch, Maria Musgaard, Rebecca Sitsapesan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a9586cc41ca240059c5cc002b05afc15
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