Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

Background: It is shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential. Objectives: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON...

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Autores principales:	Narjes Rezaei, Zahra Zaherijamil, Shirin Moradkhani, Massoud Saidijam, Iraj Khodadadi, Ebrahim Abbasi Oshaghi, Heidar Tavilani
Formato:	article
Lenguaje:	EN
Publicado:	Hamadan University of Medical Sciences 2020
Materias:	kiwifruit paraoxonase 1 liver tissue high-density lipoprotein high-fat diet Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/a96f3b1dc3344d0997eda6980c601ebf
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spelling	oai:doaj.org-article:a96f3b1dc3344d0997eda6980c601ebf2021-11-21T10:05:46ZKiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters 10.34172/ajmb.2020.092345-4113https://doaj.org/article/a96f3b1dc3344d0997eda6980c601ebf2020-12-01T00:00:00Zhttp://ajmb.umsha.ac.ir/PDF/ajmb-8-58.pdfhttps://doaj.org/toc/2345-4113Background: It is shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential. Objectives: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON1) enzyme, as a main antioxidant enzyme in HDL functionality, in a high-fat diet (HFD). Methods: To this end, 42 male Syrian hamsters were divided into 6 groups including hamsters receiving a normal diet (the control normal group), a regular diet supplemented with kiwifruit at two concentrations (i.e., 1.86 g/kg and 3.73 g/kg), a HFD comprised of 15% butterfat + 0.05% cholesterol (the control high-fat group), and a HFD supplemented with kiwifruit at two concentrations (i.e., 1.86 and 3.73 g/kg) for 8 weeks. Results: The results showed that supplementation of kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) compared with the control-HF group. In addition, the paraoxonase activity of PON1 significantly increased in HFD supplemented with kiwifruit (1.86 g/kg), and finally, arylesterase (ARE) activity increased in all treated groups when compared with untreated groups. Conclusion: Our findings suggested that kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thus increasing the ARE and paraoxonase activities of PON1. Narjes RezaeiZahra ZaherijamilShirin MoradkhaniMassoud SaidijamIraj KhodadadiEbrahim Abbasi OshaghiHeidar TavilaniHamadan University of Medical Sciencesarticlekiwifruitparaoxonase 1liver tissuehigh-density lipoproteinhigh-fat dietMedical technologyR855-855.5ENAvicenna Journal of Medical Biochemistry, Vol 8, Iss 2, Pp 58-68 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	kiwifruit paraoxonase 1 liver tissue high-density lipoprotein high-fat diet Medical technology R855-855.5
spellingShingle	kiwifruit paraoxonase 1 liver tissue high-density lipoprotein high-fat diet Medical technology R855-855.5 Narjes Rezaei Zahra Zaherijamil Shirin Moradkhani Massoud Saidijam Iraj Khodadadi Ebrahim Abbasi Oshaghi Heidar Tavilani Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters
description	Background: It is shown that kiwifruit elevates serum high-density lipoprotein cholesterol (HDL-C) levels and exhibits beneficial effects on human health due to its antioxidant potential. Objectives: This study aimed to investigate the impact of kiwifruit on the activity of the paraoxonase 1 (PON1) enzyme, as a main antioxidant enzyme in HDL functionality, in a high-fat diet (HFD). Methods: To this end, 42 male Syrian hamsters were divided into 6 groups including hamsters receiving a normal diet (the control normal group), a regular diet supplemented with kiwifruit at two concentrations (i.e., 1.86 g/kg and 3.73 g/kg), a HFD comprised of 15% butterfat + 0.05% cholesterol (the control high-fat group), and a HFD supplemented with kiwifruit at two concentrations (i.e., 1.86 and 3.73 g/kg) for 8 weeks. Results: The results showed that supplementation of kiwifruit to the HFD increased the levels of HDL-C and remarkably reduced the concentrations of oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA) compared with the control-HF group. In addition, the paraoxonase activity of PON1 significantly increased in HFD supplemented with kiwifruit (1.86 g/kg), and finally, arylesterase (ARE) activity increased in all treated groups when compared with untreated groups. Conclusion: Our findings suggested that kiwifruit can improve the lipid profile and prevent oxidative stress-induced by lipid peroxidation in hamsters receiving HFD, thus increasing the ARE and paraoxonase activities of PON1.
format	article
author	Narjes Rezaei Zahra Zaherijamil Shirin Moradkhani Massoud Saidijam Iraj Khodadadi Ebrahim Abbasi Oshaghi Heidar Tavilani
author_facet	Narjes Rezaei Zahra Zaherijamil Shirin Moradkhani Massoud Saidijam Iraj Khodadadi Ebrahim Abbasi Oshaghi Heidar Tavilani
author_sort	Narjes Rezaei
title	Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters
title_short	Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters
title_full	Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters
title_fullStr	Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters
title_full_unstemmed	Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters
title_sort	kiwifruit supplementation increases the activity of the paraoxonase enzyme and decreases oxidized low-density lipoprotein in high-fat diet fed hamsters
publisher	Hamadan University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/a96f3b1dc3344d0997eda6980c601ebf
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Kiwifruit Supplementation Increases the Activity of the Paraoxonase Enzyme and decreases Oxidized Low-Density Lipoprotein in High-Fat Diet Fed Hamsters

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