NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster within a subset of insulated domains implicating 3D c...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2019
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/a9714ab2ecf84d2fb21b384d6ebd3d76 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|