Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions

Most phasing programmes for sequencing data work well for genomes with low heterozygosity but drop in performance in regions of high heterozygosity. Here, Kajitani et al. develop the assembler Platanus-allee and demonstrate its utility in de novo assemblies of various genomes and the human MHC regio...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Rei Kajitani, Dai Yoshimura, Miki Okuno, Yohei Minakuchi, Hiroshi Kagoshima, Asao Fujiyama, Kaoru Kubokawa, Yuji Kohara, Atsushi Toyoda, Takehiko Itoh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/a9a7890c7a7f4fc695668d57d1a1ea7c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a9a7890c7a7f4fc695668d57d1a1ea7c
record_format dspace
spelling oai:doaj.org-article:a9a7890c7a7f4fc695668d57d1a1ea7c2021-12-02T16:58:00ZPlatanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions10.1038/s41467-019-09575-22041-1723https://doaj.org/article/a9a7890c7a7f4fc695668d57d1a1ea7c2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09575-2https://doaj.org/toc/2041-1723Most phasing programmes for sequencing data work well for genomes with low heterozygosity but drop in performance in regions of high heterozygosity. Here, Kajitani et al. develop the assembler Platanus-allee and demonstrate its utility in de novo assemblies of various genomes and the human MHC region.Rei KajitaniDai YoshimuraMiki OkunoYohei MinakuchiHiroshi KagoshimaAsao FujiyamaKaoru KubokawaYuji KoharaAtsushi ToyodaTakehiko ItohNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rei Kajitani
Dai Yoshimura
Miki Okuno
Yohei Minakuchi
Hiroshi Kagoshima
Asao Fujiyama
Kaoru Kubokawa
Yuji Kohara
Atsushi Toyoda
Takehiko Itoh
Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
description Most phasing programmes for sequencing data work well for genomes with low heterozygosity but drop in performance in regions of high heterozygosity. Here, Kajitani et al. develop the assembler Platanus-allee and demonstrate its utility in de novo assemblies of various genomes and the human MHC region.
format article
author Rei Kajitani
Dai Yoshimura
Miki Okuno
Yohei Minakuchi
Hiroshi Kagoshima
Asao Fujiyama
Kaoru Kubokawa
Yuji Kohara
Atsushi Toyoda
Takehiko Itoh
author_facet Rei Kajitani
Dai Yoshimura
Miki Okuno
Yohei Minakuchi
Hiroshi Kagoshima
Asao Fujiyama
Kaoru Kubokawa
Yuji Kohara
Atsushi Toyoda
Takehiko Itoh
author_sort Rei Kajitani
title Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
title_short Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
title_full Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
title_fullStr Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
title_full_unstemmed Platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
title_sort platanus-allee is a de novo haplotype assembler enabling a comprehensive access to divergent heterozygous regions
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a9a7890c7a7f4fc695668d57d1a1ea7c
work_keys_str_mv AT reikajitani platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT daiyoshimura platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT mikiokuno platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT yoheiminakuchi platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT hiroshikagoshima platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT asaofujiyama platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT kaorukubokawa platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT yujikohara platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT atsushitoyoda platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
AT takehikoitoh platanusalleeisadenovohaplotypeassemblerenablingacomprehensiveaccesstodivergentheterozygousregions
_version_ 1718382407636221952