Binding fullerenol C60(OH)24 to dsDNA
Mariana Pinteala, Andrei Dascalu, Cezar UngurenasuPetru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, Iasi, RomaniaAbstract: The first C60(OH)24-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C60(OH)24 is in proportion t...
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| Auteurs principaux: | , , |
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| Format: | article |
| Langue: | EN |
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Dove Medical Press
2009
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| Accès en ligne: | https://doaj.org/article/a9abd9a58f0a4b33a8b9bd48e5c4ea0b |
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| Résumé: | Mariana Pinteala, Andrei Dascalu, Cezar UngurenasuPetru Poni Institute of Macromolecular Chemistry, Aleea Grigore Ghica, Iasi, RomaniaAbstract: The first C60(OH)24-DNA complex and its fluorescence enhancement is reported. The enhanced fluorescence intensity of fullerenol C60(OH)24 is in proportion to the concentration of DNA in the range of 1 × 10-9 to 8 × 10-5 molL-1 and the detection limit was 1.3 ng mL-1. Fullerenol C60(OH)24 binds significantly to the phosphate backbone of native dsDNA and to base-pairs within the major groove of sodium salt of dsDNA.Keywords: nanomedicine, fullerenol, DNA complexation, fluorescent probe |
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