Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal ins...

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Autores principales:	Gaëlle Marteil, Adan Guerrero, André F. Vieira, Bernardo P. de Almeida, Pedro Machado, Susana Mendonça, Marta Mesquita, Beth Villarreal, Irina Fonseca, Maria E. Francia, Katharina Dores, Nuno P. Martins, Swadhin C. Jana, Erin M. Tranfield, Nuno L. Barbosa-Morais, Joana Paredes, David Pellman, Susana A. Godinho, Mónica Bettencourt-Dias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9b31e151bf34283b9c2a8077242da36
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spelling	oai:doaj.org-article:a9b31e151bf34283b9c2a8077242da362021-12-02T14:40:32ZOver-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation10.1038/s41467-018-03641-x2041-1723https://doaj.org/article/a9b31e151bf34283b9c2a8077242da362018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03641-xhttps://doaj.org/toc/2041-1723Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal instability.Gaëlle MarteilAdan GuerreroAndré F. VieiraBernardo P. de AlmeidaPedro MachadoSusana MendonçaMarta MesquitaBeth VillarrealIrina FonsecaMaria E. FranciaKatharina DoresNuno P. MartinsSwadhin C. JanaErin M. TranfieldNuno L. Barbosa-MoraisJoana ParedesDavid PellmanSusana A. GodinhoMónica Bettencourt-DiasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gaëlle Marteil Adan Guerrero André F. Vieira Bernardo P. de Almeida Pedro Machado Susana Mendonça Marta Mesquita Beth Villarreal Irina Fonseca Maria E. Francia Katharina Dores Nuno P. Martins Swadhin C. Jana Erin M. Tranfield Nuno L. Barbosa-Morais Joana Paredes David Pellman Susana A. Godinho Mónica Bettencourt-Dias Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
description	Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal instability.
format	article
author	Gaëlle Marteil Adan Guerrero André F. Vieira Bernardo P. de Almeida Pedro Machado Susana Mendonça Marta Mesquita Beth Villarreal Irina Fonseca Maria E. Francia Katharina Dores Nuno P. Martins Swadhin C. Jana Erin M. Tranfield Nuno L. Barbosa-Morais Joana Paredes David Pellman Susana A. Godinho Mónica Bettencourt-Dias
author_facet	Gaëlle Marteil Adan Guerrero André F. Vieira Bernardo P. de Almeida Pedro Machado Susana Mendonça Marta Mesquita Beth Villarreal Irina Fonseca Maria E. Francia Katharina Dores Nuno P. Martins Swadhin C. Jana Erin M. Tranfield Nuno L. Barbosa-Morais Joana Paredes David Pellman Susana A. Godinho Mónica Bettencourt-Dias
author_sort	Gaëlle Marteil
title	Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_short	Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_full	Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_fullStr	Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_full_unstemmed	Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
title_sort	over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a9b31e151bf34283b9c2a8077242da36
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Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

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