Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal ins...
Guardado en:
Autores principales: | Gaëlle Marteil, Adan Guerrero, André F. Vieira, Bernardo P. de Almeida, Pedro Machado, Susana Mendonça, Marta Mesquita, Beth Villarreal, Irina Fonseca, Maria E. Francia, Katharina Dores, Nuno P. Martins, Swadhin C. Jana, Erin M. Tranfield, Nuno L. Barbosa-Morais, Joana Paredes, David Pellman, Susana A. Godinho, Mónica Bettencourt-Dias |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a9b31e151bf34283b9c2a8077242da36 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors
por: Olivier Mercey, et al.
Publicado: (2019) -
Coping with centriole loss: pericentriolar material maintenance after centriole degeneration
por: Carla M. C. Abreu, et al.
Publicado: (2021) -
Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity
por: Elisa Vitiello, et al.
Publicado: (2019) -
CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion
por: Enrico S. Atorino, et al.
Publicado: (2020) -
Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis
por: Munemasa Mori, et al.
Publicado: (2017)