Microenvironment-derived factors driving metastatic plasticity in melanoma

Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the micr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Isabella S. Kim, Silja Heilmann, Emily R. Kansler, Yan Zhang, Milena Zimmer, Kajan Ratnakumar, Robert L. Bowman, Theresa Simon-Vermot, Myles Fennell, Ralph Garippa, Liang Lu, William Lee, Travis Hollmann, Joao B. Xavier, Richard M. White
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9ccb537f389465d997a19a77c63d6c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a9ccb537f389465d997a19a77c63d6c9
record_format	dspace
spelling	oai:doaj.org-article:a9ccb537f389465d997a19a77c63d6c92021-12-02T14:42:26ZMicroenvironment-derived factors driving metastatic plasticity in melanoma10.1038/ncomms143432041-1723https://doaj.org/article/a9ccb537f389465d997a19a77c63d6c92017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14343https://doaj.org/toc/2041-1723Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the microenvironment.Isabella S. KimSilja HeilmannEmily R. KanslerYan ZhangMilena ZimmerKajan RatnakumarRobert L. BowmanTheresa Simon-VermotMyles FennellRalph GarippaLiang LuWilliam LeeTravis HollmannJoao B. XavierRichard M. WhiteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabella S. Kim Silja Heilmann Emily R. Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L. Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B. Xavier Richard M. White Microenvironment-derived factors driving metastatic plasticity in melanoma
description	Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the microenvironment.
format	article
author	Isabella S. Kim Silja Heilmann Emily R. Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L. Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B. Xavier Richard M. White
author_facet	Isabella S. Kim Silja Heilmann Emily R. Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L. Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B. Xavier Richard M. White
author_sort	Isabella S. Kim
title	Microenvironment-derived factors driving metastatic plasticity in melanoma
title_short	Microenvironment-derived factors driving metastatic plasticity in melanoma
title_full	Microenvironment-derived factors driving metastatic plasticity in melanoma
title_fullStr	Microenvironment-derived factors driving metastatic plasticity in melanoma
title_full_unstemmed	Microenvironment-derived factors driving metastatic plasticity in melanoma
title_sort	microenvironment-derived factors driving metastatic plasticity in melanoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a9ccb537f389465d997a19a77c63d6c9
work_keys_str_mv	AT isabellaskim microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT siljaheilmann microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT emilyrkansler microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT yanzhang microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT milenazimmer microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT kajanratnakumar microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT robertlbowman microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT theresasimonvermot microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT mylesfennell microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT ralphgarippa microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT lianglu microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT williamlee microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT travishollmann microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT joaobxavier microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma AT richardmwhite microenvironmentderivedfactorsdrivingmetastaticplasticityinmelanoma
_version_	1718389708765003776

Microenvironment-derived factors driving metastatic plasticity in melanoma

Ejemplares similares