Surface hydrophobics mediate functional dimerization of CYP121A1 of Mycobacterium tuberculosis
Abstract Tuberculosis is caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb) and remains the leading cause of death by infection world-wide. The Mtb genome encodes a disproportionate number of twenty cytochrome P450 enzymes, of which the essential enzyme cytochrome P450 121A1 (CYP121...
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Main Authors: | Amit Kumar, Christopher S. Campomizzi, Natalie Jay, Shaun Ferguson, Emelie-Jo Scheffler, James Lioi, Chengjian Tu, Jun Qu, Claire Simons, D. Fernando Estrada |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/a9d2074e6b3a4b9bbf9546ed2afe7af6 |
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