Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

Non-heme iron and α-ketoglutarate (αKG) oxygenases play a major role in fungal meroterpenoid biosynthesis, but their mechanism remains elusive. Here the authors present crystal structures of two oxygenases, AusE and PrhA, which provide insights into the multifunctional nature of these enzymes.

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Autores principales:	Yu Nakashima, Takahiro Mori, Hitomi Nakamura, Takayoshi Awakawa, Shotaro Hoshino, Miki Senda, Toshiya Senda, Ikuro Abe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9d82d60fc91499ea620314cccccd36f
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spelling	oai:doaj.org-article:a9d82d60fc91499ea620314cccccd36f2021-12-02T16:50:11ZStructure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis10.1038/s41467-017-02371-w2041-1723https://doaj.org/article/a9d82d60fc91499ea620314cccccd36f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02371-whttps://doaj.org/toc/2041-1723Non-heme iron and α-ketoglutarate (αKG) oxygenases play a major role in fungal meroterpenoid biosynthesis, but their mechanism remains elusive. Here the authors present crystal structures of two oxygenases, AusE and PrhA, which provide insights into the multifunctional nature of these enzymes.Yu NakashimaTakahiro MoriHitomi NakamuraTakayoshi AwakawaShotaro HoshinoMiki SendaToshiya SendaIkuro AbeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Nakashima Takahiro Mori Hitomi Nakamura Takayoshi Awakawa Shotaro Hoshino Miki Senda Toshiya Senda Ikuro Abe Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
description	Non-heme iron and α-ketoglutarate (αKG) oxygenases play a major role in fungal meroterpenoid biosynthesis, but their mechanism remains elusive. Here the authors present crystal structures of two oxygenases, AusE and PrhA, which provide insights into the multifunctional nature of these enzymes.
format	article
author	Yu Nakashima Takahiro Mori Hitomi Nakamura Takayoshi Awakawa Shotaro Hoshino Miki Senda Toshiya Senda Ikuro Abe
author_facet	Yu Nakashima Takahiro Mori Hitomi Nakamura Takayoshi Awakawa Shotaro Hoshino Miki Senda Toshiya Senda Ikuro Abe
author_sort	Yu Nakashima
title	Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
title_short	Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
title_full	Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
title_fullStr	Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
title_full_unstemmed	Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
title_sort	structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a9d82d60fc91499ea620314cccccd36f
work_keys_str_mv	AT yunakashima structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT takahiromori structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT hitominakamura structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT takayoshiawakawa structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT shotarohoshino structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT mikisenda structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT toshiyasenda structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis AT ikuroabe structurefunctionandengineeringofmultifunctionalnonhemeirondependentoxygenasesinfungalmeroterpenoidbiosynthesis
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Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis

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