Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

Abstract The molecular mechanism of Endoplasmic Reticulum-associated degradation (ERAD) of Cystic fibrosis transmembrane-conductance regulator (CFTR) is largely unknown. Particularly, it is unknown what ER luminal factor(s) are involved in ERAD. Herein, we used ProtoArray to identify an ER luminal c...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yunjie Huang, Kavisha Arora, Kyu Shik Mun, Fanmuyi Yang, ChangSuk Moon, Sunitha Yarlagadda, Anil Jegga, Timothy Weaver, Anjaparavanda P. Naren
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
R
Q
Acceso en línea:https://doaj.org/article/a9ead2c7e3d246a98726846c361c73db
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!