Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR

Abstract The molecular mechanism of Endoplasmic Reticulum-associated degradation (ERAD) of Cystic fibrosis transmembrane-conductance regulator (CFTR) is largely unknown. Particularly, it is unknown what ER luminal factor(s) are involved in ERAD. Herein, we used ProtoArray to identify an ER luminal c...

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Autores principales: Yunjie Huang, Kavisha Arora, Kyu Shik Mun, Fanmuyi Yang, ChangSuk Moon, Sunitha Yarlagadda, Anil Jegga, Timothy Weaver, Anjaparavanda P. Naren
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a9ead2c7e3d246a98726846c361c73db
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