EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2.

EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2.

EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis. Here we demonstrate that EMMPRIN up-regulated VEGF receptor-2 (VEGFR-2) in two different primary melanoma cell lines and consequently increased migration and proliferation of these cells while inhibiting th...

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Autores principales: Faten Bougatef, Suzanne Menashi, Farah Khayati, Benyoussef Naïmi, Raphaël Porcher, Marie-Pierre Podgorniak, Guy Millot, Anne Janin, Fabien Calvo, Céleste Lebbé, Samia Mourah
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/aa0e8ff42c2e47909ed21d481416828f
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https://doaj.org/article/aa0e8ff42c2e47909ed21d481416828f

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