Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the primary EAC tumors and provide a platform to test...

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Autores principales:	Xiaodun Li, Hayley E. Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J. Barendt, Laura Letchford, Genevieve M. Leyden, Emma K. Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C. Wedge, Rebecca C. Fitzgerald, Mathew J. Garnett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aa2121583c394435847f94d0542851c4
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spelling	oai:doaj.org-article:aa2121583c394435847f94d0542851c42021-12-02T14:39:09ZOrganoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics10.1038/s41467-018-05190-92041-1723https://doaj.org/article/aa2121583c394435847f94d0542851c42018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05190-9https://doaj.org/toc/2041-1723Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the primary EAC tumors and provide a platform to test drug sensitivity and study tumor clonality.Xiaodun LiHayley E. FranciesMaria SecrierJuliane PernerAhmad MiremadiNúria Galeano-DalmauWilliam J. BarendtLaura LetchfordGenevieve M. LeydenEmma K. GoffinAndrew BarthorpeHoward LightfootElisabeth ChenJames GilbertAyesha NooraniGinny DevonshireLawrence BowerAmber GranthamShona MacRaeNicola GrehanDavid C. WedgeRebecca C. FitzgeraldMathew J. GarnettNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaodun Li Hayley E. Francies Maria Secrier Juliane Perner Ahmad Miremadi Núria Galeano-Dalmau William J. Barendt Laura Letchford Genevieve M. Leyden Emma K. Goffin Andrew Barthorpe Howard Lightfoot Elisabeth Chen James Gilbert Ayesha Noorani Ginny Devonshire Lawrence Bower Amber Grantham Shona MacRae Nicola Grehan David C. Wedge Rebecca C. Fitzgerald Mathew J. Garnett Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
description	Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the primary EAC tumors and provide a platform to test drug sensitivity and study tumor clonality.
format	article
author	Xiaodun Li Hayley E. Francies Maria Secrier Juliane Perner Ahmad Miremadi Núria Galeano-Dalmau William J. Barendt Laura Letchford Genevieve M. Leyden Emma K. Goffin Andrew Barthorpe Howard Lightfoot Elisabeth Chen James Gilbert Ayesha Noorani Ginny Devonshire Lawrence Bower Amber Grantham Shona MacRae Nicola Grehan David C. Wedge Rebecca C. Fitzgerald Mathew J. Garnett
author_facet	Xiaodun Li Hayley E. Francies Maria Secrier Juliane Perner Ahmad Miremadi Núria Galeano-Dalmau William J. Barendt Laura Letchford Genevieve M. Leyden Emma K. Goffin Andrew Barthorpe Howard Lightfoot Elisabeth Chen James Gilbert Ayesha Noorani Ginny Devonshire Lawrence Bower Amber Grantham Shona MacRae Nicola Grehan David C. Wedge Rebecca C. Fitzgerald Mathew J. Garnett
author_sort	Xiaodun Li
title	Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
title_short	Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
title_full	Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
title_fullStr	Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
title_full_unstemmed	Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
title_sort	organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/aa2121583c394435847f94d0542851c4
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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

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