Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-d...

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Autores principales: Marta Dueñas, Mirentxu Santos, Juan F Aranda, Concha Bielza, Ana B Martínez-Cruz, Corina Lorz, Miquel Taron, Eva M Ciruelos, José L Rodríguez-Peralto, Miguel Martín, Pedro Larrañaga, Jubrail Dahabreh, George P Stathopoulos, Rafael Rosell, Jesús M Paramio, Ramón García-Escudero
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/aa4b88e29f75412e9bf812a4c6c27a2d
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https://doaj.org/article/aa4b88e29f75412e9bf812a4c6c27a2d

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