FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

Abstract In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obst...

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Autores principales: Edward R. Smith, Sven-Jean Tan, Stephen G. Holt, Tim D. Hewitson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/aa93e77520674b35bece2d357cb8d726
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