FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Abstract In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obst...
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Autores principales: | Edward R. Smith, Sven-Jean Tan, Stephen G. Holt, Tim D. Hewitson |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/aa93e77520674b35bece2d357cb8d726 |
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