FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programm...

Full description

Saved in:
Bibliographic Details
Main Authors: Jae Hong Im, Jon N. Buzzelli, Keaton Jones, Fanny Franchini, Alex Gordon-Weeks, Bostjan Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao, Ruth J. Muschel
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/aac2c94a42384be185bf6c4fce5f6dff
Tags: Add Tag
No Tags, Be the first to tag this record!