FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programm...

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Autores principales:	Jae Hong Im, Jon N. Buzzelli, Keaton Jones, Fanny Franchini, Alex Gordon-Weeks, Bostjan Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao, Ruth J. Muschel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/aac2c94a42384be185bf6c4fce5f6dff
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spelling	oai:doaj.org-article:aac2c94a42384be185bf6c4fce5f6dff2021-12-02T16:28:52ZFGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy10.1038/s41467-020-17914-x2041-1723https://doaj.org/article/aac2c94a42384be185bf6c4fce5f6dff2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17914-xhttps://doaj.org/toc/2041-1723Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programming by anti-FGF2 blocking antibodies enhances the outcome from radiotherapy. Jae Hong ImJon N. BuzzelliKeaton JonesFanny FranchiniAlex Gordon-WeeksBostjan MarkelcJianzhou ChenJin KimYunhong CaoRuth J. MuschelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jae Hong Im Jon N. Buzzelli Keaton Jones Fanny Franchini Alex Gordon-Weeks Bostjan Markelc Jianzhou Chen Jin Kim Yunhong Cao Ruth J. Muschel FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
description	Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programming by anti-FGF2 blocking antibodies enhances the outcome from radiotherapy.
format	article
author	Jae Hong Im Jon N. Buzzelli Keaton Jones Fanny Franchini Alex Gordon-Weeks Bostjan Markelc Jianzhou Chen Jin Kim Yunhong Cao Ruth J. Muschel
author_facet	Jae Hong Im Jon N. Buzzelli Keaton Jones Fanny Franchini Alex Gordon-Weeks Bostjan Markelc Jianzhou Chen Jin Kim Yunhong Cao Ruth J. Muschel
author_sort	Jae Hong Im
title	FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
title_short	FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
title_full	FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
title_fullStr	FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
title_full_unstemmed	FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
title_sort	fgf2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/aac2c94a42384be185bf6c4fce5f6dff
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FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

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