Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We in...
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2021
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oai:doaj.org-article:aaf140224e9448f881a85a7c3a05ad812021-11-25T16:25:29ZRole of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease10.3390/antiox101116572076-3921https://doaj.org/article/aaf140224e9448f881a85a7c3a05ad812021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1657https://doaj.org/toc/2076-3921Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress.Heeyoung KangHyun Joo ShinHyeong Seok AnZhen JinJong Youl LeeJaewoong LeeKyung Eun KimEun Ae JeongKyu Yeong ChoiCatriona McLeanKun Ho LeeSoo Kyoung KimHae Ryong LeeGu Seob RohMDPI AGarticlelipocalin-2amyloid-betaneuroinflammationiron accumulationoxidative stressblood–brain barrier leakageTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1657, p 1657 (2021) |
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lipocalin-2 amyloid-beta neuroinflammation iron accumulation oxidative stress blood–brain barrier leakage Therapeutics. Pharmacology RM1-950 |
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lipocalin-2 amyloid-beta neuroinflammation iron accumulation oxidative stress blood–brain barrier leakage Therapeutics. Pharmacology RM1-950 Heeyoung Kang Hyun Joo Shin Hyeong Seok An Zhen Jin Jong Youl Lee Jaewoong Lee Kyung Eun Kim Eun Ae Jeong Kyu Yeong Choi Catriona McLean Kun Ho Lee Soo Kyoung Kim Hae Ryong Lee Gu Seob Roh Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| description |
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress. |
| format |
article |
| author |
Heeyoung Kang Hyun Joo Shin Hyeong Seok An Zhen Jin Jong Youl Lee Jaewoong Lee Kyung Eun Kim Eun Ae Jeong Kyu Yeong Choi Catriona McLean Kun Ho Lee Soo Kyoung Kim Hae Ryong Lee Gu Seob Roh |
| author_facet |
Heeyoung Kang Hyun Joo Shin Hyeong Seok An Zhen Jin Jong Youl Lee Jaewoong Lee Kyung Eun Kim Eun Ae Jeong Kyu Yeong Choi Catriona McLean Kun Ho Lee Soo Kyoung Kim Hae Ryong Lee Gu Seob Roh |
| author_sort |
Heeyoung Kang |
| title |
Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_short |
Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_full |
Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_fullStr |
Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_full_unstemmed |
Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease |
| title_sort |
role of lipocalin-2 in amyloid-beta oligomer-induced mouse model of alzheimer’s disease |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/aaf140224e9448f881a85a7c3a05ad81 |
| work_keys_str_mv |
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