Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Cytosine base editors have been reported to induce off-target mutations in DNA and RNA. Here the authors identify next-generation CBEs with reduced guide-independent off-target editing profiles and retain high on-target editing activity.

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Detalles Bibliográficos
Autores principales: Yi Yu, Thomas C. Leete, David A. Born, Lauren Young, Luis A. Barrera, Seung-Joo Lee, Holly A. Rees, Giuseppe Ciaramella, Nicole M. Gaudelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ab50974242654c18950c59b5e285c447
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