Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system

Degrons are determinants within proteins that direct programmed degradation by the ubiquitinproteasome system. Here, the authors propose a three-part degron architecture which contains an E3-ligase recognition motif, a ubiquitination site(s), and a disordered site to initiate degradation.

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Autores principales: Mainak Guharoy, Pallab Bhowmick, Mohamed Sallam, Peter Tompa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ab59f1e65dfe4c0eb87197745c6290ec
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