Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system

Degrons are determinants within proteins that direct programmed degradation by the ubiquitinproteasome system. Here, the authors propose a three-part degron architecture which contains an E3-ligase recognition motif, a ubiquitination site(s), and a disordered site to initiate degradation.

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Autores principales:	Mainak Guharoy, Pallab Bhowmick, Mohamed Sallam, Peter Tompa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab59f1e65dfe4c0eb87197745c6290ec
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spelling	oai:doaj.org-article:ab59f1e65dfe4c0eb87197745c6290ec2021-12-02T14:38:57ZTripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system10.1038/ncomms102392041-1723https://doaj.org/article/ab59f1e65dfe4c0eb87197745c6290ec2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10239https://doaj.org/toc/2041-1723Degrons are determinants within proteins that direct programmed degradation by the ubiquitinproteasome system. Here, the authors propose a three-part degron architecture which contains an E3-ligase recognition motif, a ubiquitination site(s), and a disordered site to initiate degradation.Mainak GuharoyPallab BhowmickMohamed SallamPeter TompaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mainak Guharoy Pallab Bhowmick Mohamed Sallam Peter Tompa Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
description	Degrons are determinants within proteins that direct programmed degradation by the ubiquitinproteasome system. Here, the authors propose a three-part degron architecture which contains an E3-ligase recognition motif, a ubiquitination site(s), and a disordered site to initiate degradation.
format	article
author	Mainak Guharoy Pallab Bhowmick Mohamed Sallam Peter Tompa
author_facet	Mainak Guharoy Pallab Bhowmick Mohamed Sallam Peter Tompa
author_sort	Mainak Guharoy
title	Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
title_short	Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
title_full	Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
title_fullStr	Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
title_full_unstemmed	Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
title_sort	tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ab59f1e65dfe4c0eb87197745c6290ec
work_keys_str_mv	AT mainakguharoy tripartitedegronsconferdiversityandspecificityonregulatedproteindegradationintheubiquitinproteasomesystem AT pallabbhowmick tripartitedegronsconferdiversityandspecificityonregulatedproteindegradationintheubiquitinproteasomesystem AT mohamedsallam tripartitedegronsconferdiversityandspecificityonregulatedproteindegradationintheubiquitinproteasomesystem AT petertompa tripartitedegronsconferdiversityandspecificityonregulatedproteindegradationintheubiquitinproteasomesystem
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Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system

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