Mapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerization.
The process of protein misfolding and self-assembly into various, polymorphic aggregates is associated with a number of important neurodegenerative diseases. Only recently, crystal structures of several short peptides have provided detailed structural insights into -sheet rich aggregates, known as a...
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Auteurs principaux: | Dirk Matthes, Vytautas Gapsys, Venita Daebel, Bert L de Groot |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2011
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Accès en ligne: | https://doaj.org/article/ab6fbce3cc9f4e6ca56fd3e71980b6c0 |
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