An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.
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Auteurs principaux: | , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
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Sujets: | |
Accès en ligne: | https://doaj.org/article/ab8774b12af24665974fefb843895dad |
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