An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.

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Autores principales:	Kannan Natarajan, Andrew C. McShan, Jiansheng Jiang, Vlad K Kumirov, Rui Wang, Huaying Zhao, Peter Schuck, Mulualem E. Tilahun, Lisa F. Boyd, Jinfa Ying, Ad Bax, David H. Margulies, Nikolaos G. Sgourakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab8774b12af24665974fefb843895dad
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spelling	oai:doaj.org-article:ab8774b12af24665974fefb843895dad2021-12-02T14:40:37ZAn allosteric site in the T-cell receptor Cβ domain plays a critical signalling role10.1038/ncomms152602041-1723https://doaj.org/article/ab8774b12af24665974fefb843895dad2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15260https://doaj.org/toc/2041-1723Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.Kannan NatarajanAndrew C. McShanJiansheng JiangVlad K KumirovRui WangHuaying ZhaoPeter SchuckMulualem E. TilahunLisa F. BoydJinfa YingAd BaxDavid H. MarguliesNikolaos G. SgourakisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kannan Natarajan Andrew C. McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E. Tilahun Lisa F. Boyd Jinfa Ying Ad Bax David H. Margulies Nikolaos G. Sgourakis An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
description	Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at the membrane-proximal site of the TCR.
format	article
author	Kannan Natarajan Andrew C. McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E. Tilahun Lisa F. Boyd Jinfa Ying Ad Bax David H. Margulies Nikolaos G. Sgourakis
author_facet	Kannan Natarajan Andrew C. McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E. Tilahun Lisa F. Boyd Jinfa Ying Ad Bax David H. Margulies Nikolaos G. Sgourakis
author_sort	Kannan Natarajan
title	An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
title_short	An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
title_full	An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
title_fullStr	An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
title_full_unstemmed	An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
title_sort	allosteric site in the t-cell receptor cβ domain plays a critical signalling role
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ab8774b12af24665974fefb843895dad
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An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

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