Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.

Disruptions in axonal transport have been implicated in a wide range of neurodegenerative diseases. Cramping 1 (Cra1/+) and Legs at odd angles (Loa/+) mice, with hypomorphic mutations in the dynein heavy chain 1 gene, which encodes the ATPase of the retrograde motor protein dynein, were originally r...

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Autores principales: Stephanie L Courchesne, Maria F Pazyra-Murphy, Daniel J Lee, Rosalind A Segal
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/abbbc5293cf645a0ae11be11ed4deecf
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