Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.

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Auteurs principaux: Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Science
Q
Accès en ligne:https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
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Internet

https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36

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