Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.

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Autores principales:	Marija Kojic, Monika Gaik, Bence Kiska, Anna Salerno-Kochan, Sarah Hunt, Angelo Tedoldi, Sergey Mureev, Alun Jones, Belinda Whittle, Laura A. Genovesi, Christelle Adolphe, Darren L. Brown, Jennifer L. Stow, Kirill Alexandrov, Pankaj Sah, Sebastian Glatt, Brandon J. Wainwright
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
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spelling	oai:doaj.org-article:abbd7a3dce6a4cee904088b04300ff362021-12-02T16:49:24ZElongator mutation in mice induces neurodegeneration and ataxia-like behavior10.1038/s41467-018-05765-62041-1723https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff362018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05765-6https://doaj.org/toc/2041-1723Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.Marija KojicMonika GaikBence KiskaAnna Salerno-KochanSarah HuntAngelo TedoldiSergey MureevAlun JonesBelinda WhittleLaura A. GenovesiChristelle AdolpheDarren L. BrownJennifer L. StowKirill AlexandrovPankaj SahSebastian GlattBrandon J. WainwrightNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marija Kojic Monika Gaik Bence Kiska Anna Salerno-Kochan Sarah Hunt Angelo Tedoldi Sergey Mureev Alun Jones Belinda Whittle Laura A. Genovesi Christelle Adolphe Darren L. Brown Jennifer L. Stow Kirill Alexandrov Pankaj Sah Sebastian Glatt Brandon J. Wainwright Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
description	Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.
format	article
author	Marija Kojic Monika Gaik Bence Kiska Anna Salerno-Kochan Sarah Hunt Angelo Tedoldi Sergey Mureev Alun Jones Belinda Whittle Laura A. Genovesi Christelle Adolphe Darren L. Brown Jennifer L. Stow Kirill Alexandrov Pankaj Sah Sebastian Glatt Brandon J. Wainwright
author_facet	Marija Kojic Monika Gaik Bence Kiska Anna Salerno-Kochan Sarah Hunt Angelo Tedoldi Sergey Mureev Alun Jones Belinda Whittle Laura A. Genovesi Christelle Adolphe Darren L. Brown Jennifer L. Stow Kirill Alexandrov Pankaj Sah Sebastian Glatt Brandon J. Wainwright
author_sort	Marija Kojic
title	Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
title_short	Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
title_full	Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
title_fullStr	Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
title_full_unstemmed	Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
title_sort	elongator mutation in mice induces neurodegeneration and ataxia-like behavior
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/abbd7a3dce6a4cee904088b04300ff36
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Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

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