Amide nitrogen pyramidalization changes lactam amide spinning

Cis-trans lactam amide rotation is a fundamental process and its understanding might aid molecular design. Here, the authors report the synthesis and study of bicyclic lactams which undergo spin through 360 degrees as in open-chain amides, due to the occurrence of nitrogen pyramidalization.

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Autores principales:	Yuko Otani, Xin Liu, Hisashi Ohno, Siyuan Wang, Luhan Zhai, Aoze Su, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abbe06c5c40d47119ae8d500e4816855
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spelling	oai:doaj.org-article:abbe06c5c40d47119ae8d500e48168552021-12-02T17:02:11ZAmide nitrogen pyramidalization changes lactam amide spinning10.1038/s41467-018-08249-92041-1723https://doaj.org/article/abbe06c5c40d47119ae8d500e48168552019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08249-9https://doaj.org/toc/2041-1723Cis-trans lactam amide rotation is a fundamental process and its understanding might aid molecular design. Here, the authors report the synthesis and study of bicyclic lactams which undergo spin through 360 degrees as in open-chain amides, due to the occurrence of nitrogen pyramidalization.Yuko OtaniXin LiuHisashi OhnoSiyuan WangLuhan ZhaiAoze SuMasatoshi KawahataKentaro YamaguchiTomohiko OhwadaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuko Otani Xin Liu Hisashi Ohno Siyuan Wang Luhan Zhai Aoze Su Masatoshi Kawahata Kentaro Yamaguchi Tomohiko Ohwada Amide nitrogen pyramidalization changes lactam amide spinning
description	Cis-trans lactam amide rotation is a fundamental process and its understanding might aid molecular design. Here, the authors report the synthesis and study of bicyclic lactams which undergo spin through 360 degrees as in open-chain amides, due to the occurrence of nitrogen pyramidalization.
format	article
author	Yuko Otani Xin Liu Hisashi Ohno Siyuan Wang Luhan Zhai Aoze Su Masatoshi Kawahata Kentaro Yamaguchi Tomohiko Ohwada
author_facet	Yuko Otani Xin Liu Hisashi Ohno Siyuan Wang Luhan Zhai Aoze Su Masatoshi Kawahata Kentaro Yamaguchi Tomohiko Ohwada
author_sort	Yuko Otani
title	Amide nitrogen pyramidalization changes lactam amide spinning
title_short	Amide nitrogen pyramidalization changes lactam amide spinning
title_full	Amide nitrogen pyramidalization changes lactam amide spinning
title_fullStr	Amide nitrogen pyramidalization changes lactam amide spinning
title_full_unstemmed	Amide nitrogen pyramidalization changes lactam amide spinning
title_sort	amide nitrogen pyramidalization changes lactam amide spinning
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/abbe06c5c40d47119ae8d500e4816855
work_keys_str_mv	AT yukootani amidenitrogenpyramidalizationchangeslactamamidespinning AT xinliu amidenitrogenpyramidalizationchangeslactamamidespinning AT hisashiohno amidenitrogenpyramidalizationchangeslactamamidespinning AT siyuanwang amidenitrogenpyramidalizationchangeslactamamidespinning AT luhanzhai amidenitrogenpyramidalizationchangeslactamamidespinning AT aozesu amidenitrogenpyramidalizationchangeslactamamidespinning AT masatoshikawahata amidenitrogenpyramidalizationchangeslactamamidespinning AT kentaroyamaguchi amidenitrogenpyramidalizationchangeslactamamidespinning AT tomohikoohwada amidenitrogenpyramidalizationchangeslactamamidespinning
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Amide nitrogen pyramidalization changes lactam amide spinning

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