Predicting gene expression using morphological cell responses to nanotopography

The surface nanotopography of biomaterials direct cell behavior, but screening for desired effects is inefficient. Here, the authors introduce a platform that enables prediction of nanotopography-induced gene expression changes from changes in cell morphology, including in co-culture environments.

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Detalles Bibliográficos
Autores principales:	Marie F. A. Cutiongco, Bjørn Sand Jensen, Paul M. Reynolds, Nikolaj Gadegaard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abc5b9a306914cf08639ce57a7f14882
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id	oai:doaj.org-article:abc5b9a306914cf08639ce57a7f14882
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spelling	oai:doaj.org-article:abc5b9a306914cf08639ce57a7f148822021-12-02T17:33:14ZPredicting gene expression using morphological cell responses to nanotopography10.1038/s41467-020-15114-12041-1723https://doaj.org/article/abc5b9a306914cf08639ce57a7f148822020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15114-1https://doaj.org/toc/2041-1723The surface nanotopography of biomaterials direct cell behavior, but screening for desired effects is inefficient. Here, the authors introduce a platform that enables prediction of nanotopography-induced gene expression changes from changes in cell morphology, including in co-culture environments.Marie F. A. CutiongcoBjørn Sand JensenPaul M. ReynoldsNikolaj GadegaardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie F. A. Cutiongco Bjørn Sand Jensen Paul M. Reynolds Nikolaj Gadegaard Predicting gene expression using morphological cell responses to nanotopography
description	The surface nanotopography of biomaterials direct cell behavior, but screening for desired effects is inefficient. Here, the authors introduce a platform that enables prediction of nanotopography-induced gene expression changes from changes in cell morphology, including in co-culture environments.
format	article
author	Marie F. A. Cutiongco Bjørn Sand Jensen Paul M. Reynolds Nikolaj Gadegaard
author_facet	Marie F. A. Cutiongco Bjørn Sand Jensen Paul M. Reynolds Nikolaj Gadegaard
author_sort	Marie F. A. Cutiongco
title	Predicting gene expression using morphological cell responses to nanotopography
title_short	Predicting gene expression using morphological cell responses to nanotopography
title_full	Predicting gene expression using morphological cell responses to nanotopography
title_fullStr	Predicting gene expression using morphological cell responses to nanotopography
title_full_unstemmed	Predicting gene expression using morphological cell responses to nanotopography
title_sort	predicting gene expression using morphological cell responses to nanotopography
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/abc5b9a306914cf08639ce57a7f14882
work_keys_str_mv	AT mariefacutiongco predictinggeneexpressionusingmorphologicalcellresponsestonanotopography AT bjørnsandjensen predictinggeneexpressionusingmorphologicalcellresponsestonanotopography AT paulmreynolds predictinggeneexpressionusingmorphologicalcellresponsestonanotopography AT nikolajgadegaard predictinggeneexpressionusingmorphologicalcellresponsestonanotopography
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Predicting gene expression using morphological cell responses to nanotopography

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