Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions as possible mechanisms of correlation.

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Autores principales:	Samuel W. Lukowski, Luke R. Lloyd-Jones, Alexander Holloway, Holger Kirsten, Gibran Hemani, Jian Yang, Kerrin Small, Jing Zhao, Andres Metspalu, Emmanouil T. Dermitzakis, Greg Gibson, Timothy D. Spector, Joachim Thiery, Markus Scholz, Grant W. Montgomery, Tonu Esko, Peter M. Visscher, Joseph E. Powell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abe7224d0aa64c2eb3dc8e8b4d6f7a2b
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spelling	oai:doaj.org-article:abe7224d0aa64c2eb3dc8e8b4d6f7a2b2021-12-02T15:36:58ZGenetic correlations reveal the shared genetic architecture of transcription in human peripheral blood10.1038/s41467-017-00473-z2041-1723https://doaj.org/article/abe7224d0aa64c2eb3dc8e8b4d6f7a2b2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00473-zhttps://doaj.org/toc/2041-1723Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions as possible mechanisms of correlation.Samuel W. LukowskiLuke R. Lloyd-JonesAlexander HollowayHolger KirstenGibran HemaniJian YangKerrin SmallJing ZhaoAndres MetspaluEmmanouil T. DermitzakisGreg GibsonTimothy D. SpectorJoachim ThieryMarkus ScholzGrant W. MontgomeryTonu EskoPeter M. VisscherJoseph E. PowellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel W. Lukowski Luke R. Lloyd-Jones Alexander Holloway Holger Kirsten Gibran Hemani Jian Yang Kerrin Small Jing Zhao Andres Metspalu Emmanouil T. Dermitzakis Greg Gibson Timothy D. Spector Joachim Thiery Markus Scholz Grant W. Montgomery Tonu Esko Peter M. Visscher Joseph E. Powell Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
description	Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions as possible mechanisms of correlation.
format	article
author	Samuel W. Lukowski Luke R. Lloyd-Jones Alexander Holloway Holger Kirsten Gibran Hemani Jian Yang Kerrin Small Jing Zhao Andres Metspalu Emmanouil T. Dermitzakis Greg Gibson Timothy D. Spector Joachim Thiery Markus Scholz Grant W. Montgomery Tonu Esko Peter M. Visscher Joseph E. Powell
author_facet	Samuel W. Lukowski Luke R. Lloyd-Jones Alexander Holloway Holger Kirsten Gibran Hemani Jian Yang Kerrin Small Jing Zhao Andres Metspalu Emmanouil T. Dermitzakis Greg Gibson Timothy D. Spector Joachim Thiery Markus Scholz Grant W. Montgomery Tonu Esko Peter M. Visscher Joseph E. Powell
author_sort	Samuel W. Lukowski
title	Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
title_short	Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
title_full	Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
title_fullStr	Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
title_full_unstemmed	Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
title_sort	genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/abe7224d0aa64c2eb3dc8e8b4d6f7a2b
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Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood

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