Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability

5-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient tran...

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Autores principales: Yusuke Sakai, Satoshi Kimura, Tsutomu Suzuki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e
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