Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability

5-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient tran...

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Autores principales: Yusuke Sakai, Satoshi Kimura, Tsutomu Suzuki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e
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spelling oai:doaj.org-article:abf53437c10d4b36a4dc44953cb4ea8e2021-12-02T16:57:30ZDual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability10.1038/s41467-019-10750-82041-1723https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10750-8https://doaj.org/toc/2041-17235-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient translation.Yusuke SakaiSatoshi KimuraTsutomu SuzukiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yusuke Sakai
Satoshi Kimura
Tsutomu Suzuki
Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
description 5-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient translation.
format article
author Yusuke Sakai
Satoshi Kimura
Tsutomu Suzuki
author_facet Yusuke Sakai
Satoshi Kimura
Tsutomu Suzuki
author_sort Yusuke Sakai
title Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_short Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_full Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_fullStr Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_full_unstemmed Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_sort dual pathways of trna hydroxylation ensure efficient translation by expanding decoding capability
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e
work_keys_str_mv AT yusukesakai dualpathwaysoftrnahydroxylationensureefficienttranslationbyexpandingdecodingcapability
AT satoshikimura dualpathwaysoftrnahydroxylationensureefficienttranslationbyexpandingdecodingcapability
AT tsutomusuzuki dualpathwaysoftrnahydroxylationensureefficienttranslationbyexpandingdecodingcapability
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