Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability

5-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient tran...

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Auteurs principaux:	Yusuke Sakai, Satoshi Kimura, Tsutomu Suzuki
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e
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id	oai:doaj.org-article:abf53437c10d4b36a4dc44953cb4ea8e
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spelling	oai:doaj.org-article:abf53437c10d4b36a4dc44953cb4ea8e2021-12-02T16:57:30ZDual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability10.1038/s41467-019-10750-82041-1723https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10750-8https://doaj.org/toc/2041-17235-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient translation.Yusuke SakaiSatoshi KimuraTsutomu SuzukiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Sakai Satoshi Kimura Tsutomu Suzuki Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
description	5-carboxymethoxyuridine (cmo5U) is one of the RNA modifications found in bacterial tRNA anticodons. Here the authors show that the first step of cmo5U biosynthesis from uridine is mediated by either one of two parallel factors, TrhP or TrhO, and that cmo5U modification is required for efficient translation.
format	article
author	Yusuke Sakai Satoshi Kimura Tsutomu Suzuki
author_facet	Yusuke Sakai Satoshi Kimura Tsutomu Suzuki
author_sort	Yusuke Sakai
title	Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_short	Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_full	Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_fullStr	Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_full_unstemmed	Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
title_sort	dual pathways of trna hydroxylation ensure efficient translation by expanding decoding capability
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/abf53437c10d4b36a4dc44953cb4ea8e
work_keys_str_mv	AT yusukesakai dualpathwaysoftrnahydroxylationensureefficienttranslationbyexpandingdecodingcapability AT satoshikimura dualpathwaysoftrnahydroxylationensureefficienttranslationbyexpandingdecodingcapability AT tsutomusuzuki dualpathwaysoftrnahydroxylationensureefficienttranslationbyexpandingdecodingcapability
_version_	1718382522098778112

Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability

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