EMeth: An EM algorithm for cell type decomposition based on DNA methylation data

Abstract We introduce a new computational method named EMeth to estimate cell type proportions using DNA methylation data. EMeth is a reference-based method that requires cell type-specific DNA methylation data from relevant cell types. EMeth improves on the existing reference-based methods by detec...

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Autores principales: Hanyu Zhang, Ruoyi Cai, James Dai, Wei Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ac4262b5b25c4c71920cdd02388a298b
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