Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment

Targeting histone acetylation modulators (HAMPs) is a promising avenue of drug discovery in cancer research. Here, the authors integrate multi-dimensional genomic profiles to systematically investigate recurrent genomic alterations in HAMPs, identifying potential therapeutic targets for precision ep...

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Autores principales:	Zhongyi Hu, Junzhi Zhou, Junjie Jiang, Jiao Yuan, Youyou Zhang, Xuepeng Wei, Nicki Loo, Yueying Wang, Yutian Pan, Tianli Zhang, Xiaomin Zhong, Meixiao Long, Kathleen T. Montone, Janos L. Tanyi, Yi Fan, Tian-Li Wang, Ie-Ming Shih, Xiaowen Hu, Lin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac4b69723bc14d03a184d8c6e51e4ce5
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spelling	oai:doaj.org-article:ac4b69723bc14d03a184d8c6e51e4ce52021-12-02T17:02:02ZGenomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment10.1038/s41467-019-08554-x2041-1723https://doaj.org/article/ac4b69723bc14d03a184d8c6e51e4ce52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08554-xhttps://doaj.org/toc/2041-1723Targeting histone acetylation modulators (HAMPs) is a promising avenue of drug discovery in cancer research. Here, the authors integrate multi-dimensional genomic profiles to systematically investigate recurrent genomic alterations in HAMPs, identifying potential therapeutic targets for precision epigenetic treatment.Zhongyi HuJunzhi ZhouJunjie JiangJiao YuanYouyou ZhangXuepeng WeiNicki LooYueying WangYutian PanTianli ZhangXiaomin ZhongMeixiao LongKathleen T. MontoneJanos L. TanyiYi FanTian-Li WangIe-Ming ShihXiaowen HuLin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongyi Hu Junzhi Zhou Junjie Jiang Jiao Yuan Youyou Zhang Xuepeng Wei Nicki Loo Yueying Wang Yutian Pan Tianli Zhang Xiaomin Zhong Meixiao Long Kathleen T. Montone Janos L. Tanyi Yi Fan Tian-Li Wang Ie-Ming Shih Xiaowen Hu Lin Zhang Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
description	Targeting histone acetylation modulators (HAMPs) is a promising avenue of drug discovery in cancer research. Here, the authors integrate multi-dimensional genomic profiles to systematically investigate recurrent genomic alterations in HAMPs, identifying potential therapeutic targets for precision epigenetic treatment.
format	article
author	Zhongyi Hu Junzhi Zhou Junjie Jiang Jiao Yuan Youyou Zhang Xuepeng Wei Nicki Loo Yueying Wang Yutian Pan Tianli Zhang Xiaomin Zhong Meixiao Long Kathleen T. Montone Janos L. Tanyi Yi Fan Tian-Li Wang Ie-Ming Shih Xiaowen Hu Lin Zhang
author_facet	Zhongyi Hu Junzhi Zhou Junjie Jiang Jiao Yuan Youyou Zhang Xuepeng Wei Nicki Loo Yueying Wang Yutian Pan Tianli Zhang Xiaomin Zhong Meixiao Long Kathleen T. Montone Janos L. Tanyi Yi Fan Tian-Li Wang Ie-Ming Shih Xiaowen Hu Lin Zhang
author_sort	Zhongyi Hu
title	Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
title_short	Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
title_full	Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
title_fullStr	Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
title_full_unstemmed	Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
title_sort	genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ac4b69723bc14d03a184d8c6e51e4ce5
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Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment

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