Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.

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Autores principales: Si Naftaly, Itay Cohen, Anat Shahar, Alexandra Hockla, Evette S. Radisky, Niv Papo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
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