Ubiquitination of stalled ribosome triggers ribosome-associated quality control

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

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Detalles Bibliográficos
Autores principales: Yoshitaka Matsuo, Ken Ikeuchi, Yasushi Saeki, Shintaro Iwasaki, Christian Schmidt, Tsuyoshi Udagawa, Fumiya Sato, Hikaru Tsuchiya, Thomas Becker, Keiji Tanaka, Nicholas T. Ingolia, Roland Beckmann, Toshifumi Inada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/ac79e96cca5545dc9617e0b5a03d81ec
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https://doaj.org/article/ac79e96cca5545dc9617e0b5a03d81ec

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