Ubiquitination of stalled ribosome triggers ribosome-associated quality control

Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

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Autores principales:	Yoshitaka Matsuo, Ken Ikeuchi, Yasushi Saeki, Shintaro Iwasaki, Christian Schmidt, Tsuyoshi Udagawa, Fumiya Sato, Hikaru Tsuchiya, Thomas Becker, Keiji Tanaka, Nicholas T. Ingolia, Roland Beckmann, Toshifumi Inada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac79e96cca5545dc9617e0b5a03d81ec
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spelling	oai:doaj.org-article:ac79e96cca5545dc9617e0b5a03d81ec2021-12-02T10:48:10ZUbiquitination of stalled ribosome triggers ribosome-associated quality control10.1038/s41467-017-00188-12041-1723https://doaj.org/article/ac79e96cca5545dc9617e0b5a03d81ec2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00188-1https://doaj.org/toc/2041-1723Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.Yoshitaka MatsuoKen IkeuchiYasushi SaekiShintaro IwasakiChristian SchmidtTsuyoshi UdagawaFumiya SatoHikaru TsuchiyaThomas BeckerKeiji TanakaNicholas T. IngoliaRoland BeckmannToshifumi InadaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshitaka Matsuo Ken Ikeuchi Yasushi Saeki Shintaro Iwasaki Christian Schmidt Tsuyoshi Udagawa Fumiya Sato Hikaru Tsuchiya Thomas Becker Keiji Tanaka Nicholas T. Ingolia Roland Beckmann Toshifumi Inada Ubiquitination of stalled ribosome triggers ribosome-associated quality control
description	Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.
format	article
author	Yoshitaka Matsuo Ken Ikeuchi Yasushi Saeki Shintaro Iwasaki Christian Schmidt Tsuyoshi Udagawa Fumiya Sato Hikaru Tsuchiya Thomas Becker Keiji Tanaka Nicholas T. Ingolia Roland Beckmann Toshifumi Inada
author_facet	Yoshitaka Matsuo Ken Ikeuchi Yasushi Saeki Shintaro Iwasaki Christian Schmidt Tsuyoshi Udagawa Fumiya Sato Hikaru Tsuchiya Thomas Becker Keiji Tanaka Nicholas T. Ingolia Roland Beckmann Toshifumi Inada
author_sort	Yoshitaka Matsuo
title	Ubiquitination of stalled ribosome triggers ribosome-associated quality control
title_short	Ubiquitination of stalled ribosome triggers ribosome-associated quality control
title_full	Ubiquitination of stalled ribosome triggers ribosome-associated quality control
title_fullStr	Ubiquitination of stalled ribosome triggers ribosome-associated quality control
title_full_unstemmed	Ubiquitination of stalled ribosome triggers ribosome-associated quality control
title_sort	ubiquitination of stalled ribosome triggers ribosome-associated quality control
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ac79e96cca5545dc9617e0b5a03d81ec
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Ubiquitination of stalled ribosome triggers ribosome-associated quality control

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